Assassination is the ultimate pwnage of a famous dude, always generating drama and, usually, drawn-out trials that will be shown on television. It is difficult to assassinate someone on the internet, but that doesn't stop people from saying they'd like to try. If successful, the last you'll see of your opponent is on teh reruns, kiddo.
I wish you were dead, I wish you were. When all I have is you, Inside my head, You're in my head, And it would be much easier if you were dead... ---Scheer: I Wish You Were Dead
The kinds of people you can assassinate are practically infinite. You have to be subtle though. Popping them with a shotgun will allow the lulz to run wild, but you'll probably be jailed by the FBI and end up like this guy.
Traditionally, bitches have assassinated their favorite famous dudes by poisoning them. And it was very effective, until the forensic police bred like rabbits. Now you can't even get away with shooting up a hobo with cyanide.